ETIDIoH<p><strong>Avian <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/influenza-2/" target="_blank">#influenza</a> A (#H5N1) virus in dairy <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/cattle/" target="_blank">#cattle</a>: #origin, <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/evolution/" target="_blank">#evolution</a>, and cross-species #transmission</strong></p><p>Source: mBio, <a href="https://journals.asm.org/doi/10.1128/mbio.02542-24" rel="nofollow noopener noreferrer" target="_blank">https://journals.asm.org/doi/10.1128/mbio.02542-24</a> </p><p><strong><em><span>ABSTRACT</span></em></strong><br>Since the emergence of <strong>highly pathogenic avian influenza virus (HPAIV) H5N1 of clade 2.3.4.4b </strong>as a novel reassortant virus from subtype <strong>H5N8</strong>, the virus has led to <strong>a massive number of outbreaks worldwide in wild and domestic birds</strong>. Compared to the parental HPAIV <strong>H5N8 clade 2.3.4.4b, </strong>the novel reassortant HPAIV <strong>H5N1 </strong>displayed <strong>an increased ability to escape species barriers </strong>and infect <strong>multiple mammalian species</strong>, including <strong>humans</strong>. The virus host range has been recently expanded to include <strong>ruminants</strong>, particularly <strong>dairy cattle </strong>in the United States, where <strong>cattle-to-cattle transmission </strong>was reported. As with the avian 2.3.4.4.b H5N1 viruses, the <strong>cattle-infecting virus </strong>was found to transmit from cattle to other contact animals including <strong>cats, raccoons, rodents, opossums, and poultry</strong>. Although <strong>replication of the virus in cows appears to be mainly confined to the mammary tissue</strong>, with high levels of <strong>viral loads </strong>detected in <strong>milk</strong>, infected <strong>cats and poultry </strong>showed <strong>severe respiratory disease</strong>, <strong>neurologic signs</strong>, and eventually died. Furthermore, <strong>several human infections </strong>with HPAIV H5N1 have also been reported in <strong>dairy farm workers </strong>and were attributed to exposures to infected dairy cattle. This is believed to represent the first <strong>mammalian-to-human transmission report of the HPAIV H5N1. </strong>Fortunately, <strong>infection in humans and cows</strong>, as opposed to other animals, appears to be <strong>mild in most cases</strong>. Nevertheless, the H5N1 <strong>bovine outbreak </strong>represents the largest outbreak of the H5N1 in a domestic mammal close to humans, <strong>increasing the risk that this already mammalian adapted H5N1 further adapts to human-to-human transmission and starts a pandemic</strong>. Herein, we discuss the epidemiology, evolution, pathogenesis, and <strong>potential impact </strong>of the recently identified HPAIV H5N1 clade 2.3.4.4b in dairy cattle in the United States. Eventually, interdisciplinary cooperation under a One Health framework is required to be able to control this ongoing HPAIV H5N1 outbreak to stop it before further expansion of its host range and geographical distribution.</p><p>_____</p><p><span></span></p><p><a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/ah5n1-2/" target="_blank">#aH5n1</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/ah5n8-2/" target="_blank">#aH5n8</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/abstract/" target="_blank">#abstract</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/avian-influenza-2/" target="_blank">#avianInfluenza</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/avian-influenza/" target="_blank">#AVIANINFLUENZA</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/bird-flu/" target="_blank">#birdFlu</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/cats-2/" target="_blank">#cats</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/dairy-cow/" target="_blank">#dairyCow</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/h5n1/" target="_blank">#h5n1</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/health/" target="_blank">#health</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/human-2/" target="_blank">#human</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/news/" target="_blank">#news</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/pandemic-influenza-2/" target="_blank">#pandemicInfluenza</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/poultry-2/" target="_blank">#poultry</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/reassortant-strain-2/" target="_blank">#reassortantStrain</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/research-2/" target="_blank">#research</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/usa/" target="_blank">#USA</a></p>