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#cancer

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The mRNA technology behind coronavirus vaccines is now being used to create bespoke vaccines for cancer patients.

"Cancer vaccines weren’t a proper field of research before the pandemic. There was nothing. Apart from one exception, pretty much every clinical trial had failed. With the pandemic, however, we proved that mRNA vaccines were possible.

mRNA cancer vaccines work by giving the body instructions to make a harmless piece of a cancer-related protein. This trains the immune system to recognize and attack cancer cells carrying that protein. Think of it like a training manual for security guards. The vaccine gives the immune system a guide on what cancer looks like, so it knows exactly who to watch for and remove.

Going from mRNA Covid vaccines to mRNA cancer vaccines is straightforward: same fridges, same protocol, same drug, just a different patient.

In the current trials, we do a biopsy of the patient, sequence the tissue, send it to the pharmaceutical company, and they design a personalized vaccine that’s bespoke to that patient’s cancer. That vaccine is not suitable for anyone else. It’s like science fiction.

The UK was ready. We had fridges and we had world-class manufacturing and research facilities. During the pandemic, we had proven we could open and deliver clinical trials fast. Also, the UK had established a genomic global lead with Genomics England and the 100,000 Genome Project. All doctors and nurses in this country are trained in genomics.

So the UK government signed two partnerships: one with BioNTech to provide 10,000 patients with access to personalized cancer treatments by 2030, and a 10-year investment with Moderna in an innovation and technology center with capacity to produce up to 250 million vaccines. The stars were aligned.

For many years, we believed that research is inherently slow. It used to take 20 years to get a drug to market. Most cancer patients, unfortunately, will succumb by the time a drug gets to market. We showed the world that it could be done in a year if you modernize your process, run parts of the process in parallel, and use digital tools.

We have a trial to stop skin cancer coming back after you cut it out. It’s now completed. We over-recruited again, just like every single one of the trials that we ran, and the trial finished one year ahead of schedule. That’s completely unheard of in cancer trials because they normally run over-long.

What will happen now is that, over the next six to 12 months, we will monitor the people in the trial and work out if there’s a difference between the people who took the cancer vaccine and the ones who didn’t. We’re hoping to have results by the end of the year or beginning of 2026. If it’s successful, we will have invented the first approved personalized mRNA vaccine, within only five years of the first licensed mRNA vaccine for Covid. That’s pretty impressive."

- Dr. Lennard Lee, UK National Health Service oncologist and medical director at the Ellison Institute of Technology in Oxford

wired.com/story/wired-health-l

WIRED · Covid Vaccines Have Paved the Way for Cancer VaccinesBy João Medeiros

Propublica: National Cancer Institute Employees Can’t Publish Information on These Topics Without Special Approval

Vaccines. Fluoride. Autism. Communications involving these and 20 other “controversial, high profile, or sensitive” topics will get extra scrutiny

propublica.org/article/nationa

ProPublicaNational Cancer Institute Employees Can’t Publish Information on These Topics Without Special Approval
More from ProPublica

“Scientists have uncovered a surprising role played by long non-coding RNA, particularly NEAT1, in stabilizing the genome. Their findings suggest that NEAT1, when highly methylated, helps the cell recognize and repair broken DNA strands more efficiently. This discovery could pave the way for new cancer treatments targeting tumors with high NEAT1 expression.”

scitechdaily.com/scientists-ju

Half a million people worldwide are diagnosed with esophageal #cancer every year. It is one of the deadliest forms of cancer.

A clinical study with significant involvement from University of Leipzig Medical Center shows how the chances of recovery for patients can be improved. “The chances of recovery increase significantly when surgery is combined with additional perioperative therapies,” says Professor Florian Lordick,

uni-leipzig.de/en/newsdetail/a

www.uni-leipzig.deImproved chances of recovery from oesophageal cancerEvery year, half a million people around the world develop oesophageal cancer. It is one of the most deadly types of cancer. A clinical trial, in which the University of Leipzig Medical Center played a key role, has now shown how patients’ chances of recovery can be improved. The results have been published in the New England Journal of Medicine.

Tattoo ink exposure is associated with lymphoma and skin cancers

Tattoo ink transfesr from skin to blood and accumulate in lymph nodes. Tattoo ink induces inflammation, leading to chronic inflammation and increasing risk of abnormal cell proliferation, especially skin cancer and lymphoma.

#Tattoo #Cancer #Lymphona #Health

bmcpublichealth.biomedcentral.

BioMed CentralTattoo ink exposure is associated with lymphoma and skin cancers – a Danish study of twins - BMC Public HealthBackground We aim to study the potential association between tattoo ink exposure and development of certain types of cancers in the recently established Danish Twin Tattoo Cohort. Tattoo ink is known to transfer from skin to blood and accumulate in regional lymph nodes. We are concerned that tattoo ink induces inflammation at the deposit site, leading to chronic inflammation and increasing risk of abnormal cell proliferation, especially skin cancer and lymphoma. Methods We conducted two designs of twin studies to improve confounder control: A cohort study of 2,367 randomly selected twins and a case-control study of 316 twins born in the period 1960–1996. Cancer diagnoses (ICD-10) were retrieved from the Danish Cancer Registry and tattoo ink exposure from the Danish Twin Tattoo survey from 2021. The analysis addressed effects of time-varying exposure. Results In the case-control study, individual-level analysis resulted in a hazard of skin cancer (of any type except basal cell carcinoma) that was 1.62 times higher among tattooed individuals (95% CI: 1.08–2.41). Twin-matched analysis of 14 twin pairs discordant for tattoo ink exposure and skin cancer showed HR = 1.33 (95% CI: 0.46–3.84). For skin cancer and lymphoma, increased hazards were found for tattoos larger than the palm of a hand: HR = 2.37 (95% CI: 1.11–5.06) and HR = 2.73 (95% CI: 1.33–5.60), respectively. In the cohort study design, individual-level analysis resulted in a hazard ratio of 3.91 (95% CI: 1.42–10.8) for skin cancer and 2.83 (95% CI: 1.30–6.16) for basal cell carcinoma. Conclusion In conclusion, our study suggests an increased hazard of lymphoma and skin cancers among tattooed individuals, demonstrated through two designs: a twin cohort and a case-cotwin study. We are concerned that tattoo ink interacting with surrounding cells may have severe consequences. Studies that pinpoint the etiological pathway of tattoo ink induced carcinogenesis are recommended to benefit public health.

"Ingredients that can cause cancer were found in 10 synthetic hair products used in braids, extensions and other hairstyles popular with Black women, including artificial hair from popular brands such as Magic Fingers, Sensationnel and Shake-N-Go, according to a Consumer Reports study published Thursday."

nbcnews.com/news/nbcblk/synthe

NBC News · Synthetic hair marketed to Black women contains carcinogens and lead, report findsBy Kaitlyn Schwanemann

Lynn Dekleva, who recently took a senior role at the agency, once led an aggressive effort by industry to block regulations on formaldehyde.

Make Cancer Great Again!

She Lobbied for a Carcinogen. Now She’s at the E.P.A., Approving New Chemicals.
nytimes.com/2025/02/26/climate

The New York Times · She Lobbied for Formaldehyde. Now She’s at E.P.A. Approving New Chemicals.By Hiroko Tabuchi

How AI-enhanced imaging technology helps better detect and treat breast cancer
Researchers from University of Waterloo have developed a new imaging technology that uses AI to improve breast cancer detection and treatment. Amy Tai, one of the researchers, explains how the technology works and what they're doing...
#technology #medicine #cancer #research #News #Canada
cbc.ca/news/canada/kitchener-w

#ScienceUnderSiege: The Orlando Research Conference Fallout

Something alarming is happening in the #ScientificCommunity, and it’s not getting the attention it deserves. A recent #NIH-backed #neuroscience conference in #Orlando turned into a disaster. Research sessions were canceled after being mistaken for “#DEI” initiatives, and funding was pulled.

One session on the diversity of afferent firing in the cochlea (how nerve cells transmit sound) was targeted because people saw the word “#diversity” and assumed it was political. #MAGA hat-wearing attendees reportedly vandalized posters.

The nescient reaction of the MAGA hat-wearing attendees to the word “diversity”—mistaking a scientific discussion on neural firing patterns in the cochlea for a political agenda—exemplifies a dangerous blend of #ignorance and ideological rigidity. Their inability to differentiate between linguistic context and #partisan buzzwords not only disrupted legitimate research but also underscored the broader issue of anti-intellectualism undermining scientific progress.

Worse, researchers discovered their already earned funding was revoked, postdoc opportunities disappeared, and the conference felt like a #funeral for the field as careers crumbled in real time.

Meanwhile, the NIH was banned from attending due to a new administration-imposed blackout on communications and travel, delaying critical #research on #Cancer, #HeartDisease, and #Diabetes.

#Science depends on open inquiry—but now, #political interference is gutting #research. This isn’t just about one conference. It’s a direct attack on scientific progress. If we don’t stand up now, what’s next?

🔬 Science must remain free from political control.

#ScienceUnderAttack #ResearchMatters #SaveScience #FreedomOfInquiry #ScienceNotPolitics #AcademicFreedom